產品詳情
簡單介紹：
Anti-HIP1抗體產品質量穩定，實驗效果明顯，貨期快，價格優惠，歡迎垂詢訂購！我公司長期供應**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-HIP1抗體用于**組化實驗,WB實驗,相應的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹：
Rabbit Anti-HIP1
Cat. Number:
Anti-HIP1抗體KL-11701R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene productAnti-HIP1抗體 huntingtin. HIP1 (huntingtin-interacting protein 1), a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels, and exhibits nearly identical subcellular fractionation as huntingtin. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.
Also known as:
Huntingtin Interacting Protein HIP1; Anti-HIP1抗體HIP I; HIP-1; HIP-I; hip1; HIP1/PDGFRB fusion gene; HIP1/PDGFRB fusion gene, included; HIP1_HUMAN; HIPI; Huntingtin interacting protein 1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I; ILWEQ; KIAA4113; MGC126506; MGC27616; mKIAA4113.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, .
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Immunogen: KLH conjugated synthetic peptide derived from human HIP1 (40.
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Predicted Molecular Weight: 116kDa.Anti-HIP1抗體
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications. Anti-HIP1抗體
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-HIP1抗體
Optimal working dilutions must be determined by the end user.
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