產(chǎn)品詳情
簡單介紹：
Anti-HECW1抗體產(chǎn)品質(zhì)量穩(wěn)定，實驗效果明顯，貨期快，價格優(yōu)惠，歡迎垂詢訂購！我公司長期供應(yīng)**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關(guān)試劑、熒光標(biāo)記抗體、單克隆抗體、多克隆抗體、各種標(biāo)記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-HECW1抗體用于**組化實驗,WB實驗,相應(yīng)的標(biāo)記抗體有HRP標(biāo)記抗體,FITC標(biāo)記,BIO等。
詳情介紹：
Rabbit Anti-HECW1
Cat. Number:
Anti-HECW1抗體KL-11692R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
NEDL1 is a 1,606 amino acid cytoplasmic protein predominantly expressed in neurons of ***** and fetal brain. NEDL1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to Anti-HECW1抗體substrates targeted for degradation. NEDL1 mediates ubiquitination and subsequent degradation of Dvl-1 and targets mutant SOD-1. NEDL1 forms cytotoxic aggregates with Dvl, TRAP-?and mutant SOD1 that lead to motor neuron death in FALS (familial amyotrophic lateral sclerosis). individuals affect by FALS (also known as Lou Gehrig's disease) experience muscle weakness and atrophy throughout the body. FALS is caused by the degeneration of upper and lower motor neurons resulting in loss of signal to muscles.
Also known as:
NEDL1; C2 and WW domain-containingAnti-HECW1抗體 protein 1; E3 ubiquitin-protein ligase HECW1; HECT; HECT type E3 ubiquitin ligase; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; HECT, C2 and WW domain-containing protein 1; HECW 1; Hecw1; HECW1_HUMAN; hNEDL1; NEDD4 like ubiquitin protein ligase 1; NEDD4-like E3 ubiquitin-protein ligase 1; NEDL-1; NEDL 1.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Chicken, Anti-HECW1抗體Dog, Cow, .
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Immunogen: KLH conjugated synthetic peptide derived from human HECW1 (2.
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Predicted Molecular Weight: 179kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications. Anti-HECW1抗體
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-HECW1抗體
Optimal working dilutions must be determined by the end user.
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