產(chǎn)品詳情
簡單介紹：
Anti-CDKN2A/p14ARF抗體產(chǎn)品質(zhì)量穩(wěn)定，實驗效果明顯，貨期快，價格優(yōu)惠，歡迎垂詢訂購！我公司長期供應(yīng)**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關(guān)試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-CDKN2A/p14ARF抗體用于**組化實驗,WB實驗,相應(yīng)的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹：
Rabbit Anti-CDKN2A/p14ARF
Cat. Number:
Anti-CDKN2A/p14ARF抗體KL-1174R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
This gene generates several transcript variants which differ in their first exons. At least three alternatively splicedAnti-CDKN2A/p14ARF抗體 variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. CDKN2A.
Also known as:
CD2A2_HUMAN; p14 Anti-CDKN2A/p14ARF抗體ARF; TP16; p16; CDKN2; MTS1; INK4a; CMM2; MLM; ARF; p16INK4a; INK4; p16-INK4a; p14; p16-INK4; p16INK4A; p16INK4; p19; p19ARF; CDK4I; MTS-1.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Mouse, Rat, .
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Immunogen: KLH conjugated synthetic peptide derived from human CDKN2A/p14ARF.
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Predicted Molecular Weight: 19kDa.
Storage:
Shipped at 4℃, Store Anti-CDKN2A/p14ARF抗體at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:100-500
Not yet tested in other applications.
Optimal working Anti-CDKN2A/p14ARF抗體dilutions must be determined by the end user.
Not yet tested in other applications.
Optimal working Anti-CDKN2A/p14ARF抗體dilutions must be determined by the end user.
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